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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.

Abstract Source:

J Forensic Leg Med. 2007 Feb;14(2):87-91. PMID: 19757213

Abstract Author(s):

Guang-hui Li, Dong-lin Wang, Yi-de Hu, Ping Pu, De-zhi Li, Wei-dong Wang, Bo Zhu, Ping Hao, Jun Wang, Xian-qiong Xu, Jiu-qing Wan, Yi-bing Zhou, Zheng-tang Chen

Article Affiliation:

Institute for Cancer Research in People's Liberation Army, Xinqiao Hospital, Third Military Medical University, 400037, Chongqing, China.

Abstract:

Radiation-induced acute intestinal symptoms (RIAISs) are the most relevant complication of abdominal or pelvic radiation. Considering the negative impact of RIAIS on patients' daily activities, the preventive effects of berberine on RIAIS in patients were investigated. Thirty-six patients with seminoma or lymphomas were randomized to receive berberine oral (n = 18) or not (n = 18). Forty-two patients with cervical cancer were randomized to a trial group (n = 21) and control group (n = 21). Radiotherapy used a parallel opposed anterior and posterior. 300-mg berberine was administered orally three times daily in trial groups. Eight patients with RIAIS were treated with 300-mg berberine three times daily from the third to the fifth week. Toxicities, such as fatigue, anorexia/nausea, etc., were graded weekly according to CTC version 2.0. Patients with abdominal/pelvic radiation in the control group showed grade 1 fatigue, anorexia/nausea, colitis, vomiting, proctitis, weight loss, diarrhea and grade 2 anorexia/nausea, fatigue. Only grade 1 colitis, anorexia/nausea, and fatigue were seen in patients of abdominal radiation treated with berberine. Grade 1 fatigue, colitis, anorexia/nausea, and proctitis occurred in patients of pelvic radiotherapy treated with berberine. Pretreatment with berberine significantly decreased the incidence and severity of RIAIS in patients with abdominal/pelvic radiotherapy when compared with the patients of the control group (P<0.05). RIAIS were reduced in patients with abdominal radiotherapy/pelvic radiation after receiving berberine treatment. Berberine significantly reduced the incidence and severity of RIAIS and postponed the occurrence of RIAIS in patients with abdominal or whole pelvic radiation.

Study Type : Human Study
Additional Links
Pharmacological Actions : Radioprotective : CK(858) : AC(293)
Anti Therapeutic Actions : Radiotherapy : CK(415) : AC(73)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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