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Abstract Title:

Sulfated beta-glucan derived from oat bran with potent anti-HIV activity.

Abstract Source:

Planta Med. 2002 May;68(5):397-401. PMID: 18376844

Abstract Author(s):

Shun Chun Wang, S W Annie Bligh, Chang Lian Zhu, Song Shan Shi, Zheng Tao Wang, Zhi Bi Hu, John Crowder, Christopher Branford-White, Cherelyn Vella

Abstract:

China is a major producer of oats; the annual harvested area of 350,000 ha yields approximately 465,000 tons, giving an average yield of 1.33 tons/ha. The bran is not used for animal feed as it is of poor digestibility and low nutritive content and is considered a waste byproduct. Therefore, it is advantageous to produce a value-added product from the bran. We extracted the native polysaccharide, a linear (1-3)-, (1-4)-linked beta-glucan (OBG) from the oat bran and synthesized a sulfated derivative OBGS containing 36.5% sulfate. OBGS had potent activity against a primary isolate of human immunodeficiency virus (HIV-1) in peripheral blood mononuclear cells at a concentration (EC(50)=5.98 x 10(-4) microM) approximately 15,000 times below its cytotoxic concentration. OBGS was also active postinfection (EC(50)=5.3 x 10(-4) microM) and protected pretreated peripheral mononuclear cells (EC(50)=5.2 x 10(-2) microM) washed free of the compounds prior to infection. Thus, OBGS has potential as a vaginal microbicide and is the first such report for oat bran derived sulfated beta-glucan.

Study Type : In Vitro Study

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Sayer Ji
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