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Article Publish Status: FREE
Abstract Title:

Bioactive Turmerosaccharides fromExtract (NR-INF-02): Potential Ameliorating Effect on Osteoarthritis Pain.

Abstract Source:

Pharmacogn Mag. 2017 Oct ;13(Suppl 3):S623-S627. Epub 2017 Jul 18. PMID: 29142423

Abstract Author(s):

Bharathi Bethapudi, Sasikumar Murugan, Ramanaiah Illuri, Deepak Mundkinajeddu, Chandrasekaran Chinampudur Velusami

Article Affiliation:

Bharathi Bethapudi

Abstract:

Background: has long history of medicinal use in Ayurveda. A unique product NR-INF-02 was prepared fromthat was standardized to contain turmerosaccharides.

Objective: The present study investigated the effect of turmerosaccharides rich fraction of NR-INF-02 on monosodium iodoacetate (MIA)-induced OA pain animal model that mimics human OA. Further, the analgesic effect of turmerosaccharides rich fraction was compared to turmerosaccharides less fraction of NR-INF-02.

Materials and Methods: OA pain was chemically induced by intra-articular administration of single dose of 25μl of 0.9% saline containing 0.3 mg MIA into the right knee of male albino Wistar rat. Turmerosaccharides rich fraction and turmerosaccharides less fraction (at 22.5, 45 and 90 mg/kg rat body weight dose levels) were administered as a single dose orally on day 5 of post-MIA injection. OA pain was measured using hind limb weight-bearing ability at 1, 3, 6, and 24 h post-test substance administration on day 5.

Results: Oral administration of turmerosaccharides rich fraction and turmerosaccharides less fraction (at 45 and 90 mg/kg) although significantly decreased the OA pain at all the intervals, the effect of turmerosaccharides rich fraction (57%) on OA pain was superior to turmerosaccharides less fraction (35%).

Conclusion: Bioactive turmerosaccharides fromextract contribute to the observed anti-arthritic effect in rats.

SUMMARY: Osteoarthritic pain was induced by intra-articular injection of MIA into the right kneeSingle administration of TRF/TLF on day 5 resulted in dose-dependent significant reduction of OA painTRF showed better analgesic activity than TLFTRF at 45 and 90 mg/kg has similar effects on OA pain as that of tramadolTurmerosaccharides identified as bioactive constituents ofextract.MIA: Monosodium iodoacetate; i.ar: Intra-articular; OA: Osteoarthritis; TRF: Turmerosaccharides rich fraction; TLF: Turmerosaccharides less fraction; PGE2: Prostaglandin E2; ROS: Reactive oxygen species.

Study Type : Animal Study

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