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Article Publish Status: FREE
Abstract Title:

Transcription factor activity of estrogen receptorα activation upon nonylphenol or bisphenol A treatment enhances the in vitro proliferation, invasion, and migration of neuroblastoma cells.

Abstract Source:

Onco Targets Ther. 2016 ;9:3451-63. Epub 2016 Jun 13. PMID: 27366082

Abstract Author(s):

Hongda Ma, Yao Yao, Changli Wang, Liyu Zhang, Long Cheng, Yiren Wang, Tao Wang, Erguang Liang, Hui Jia, Qinong Ye, Mingxiao Hou, Fan Feng

Article Affiliation:

Hongda Ma

Abstract:

Many kinds of endocrine-disrupting chemicals (EDCs), for example, the environmental estrogens bisphenol A and nonylphenol, may regulate the activity of estrogen receptorα (ERα) and therefore induce potential disruption of normal endocrine function. However, the involvement of EDCs in human cancers, especially in endocrine-related cancer neuroblastoma regulation, is not very clear. In this work, results showed that upon bisphenol A or nonylphenol treatment, the transcription factor activity of ERα was significantly increased in neuroblastoma cell line SH-SY5Y. Bisphenol A and nonylphenol could enhance ERα activity via recruiting it to the target gene promoter. Furthermore, treatment of bisphenol A and nonylphenol enhanced the in vitro proliferation, invasion, and migration ability of neuroblastoma cells. By investigating the role of EDC-induced ERα upregulation, our data extend the understanding of the function of EDCs and further suggest that ERα might be a potential therapeutic target in human neuroblastoma treatment.

Study Type : In Vitro Study

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Sayer Ji
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