Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

n/a
Article Publish Status: FREE
Abstract Title:

BKchannel is a molecular target of vitamin C to protect against ischemic brain stroke.

Abstract Source:

Mol Membr Biol. 2019 Apr 16:1-25. Epub 2019 Apr 16. PMID: 30991005

Abstract Author(s):

Luyao Li, Shan Li, Chuanbing Hu, Li Zhou, Yujiao Zhang, Mingyan Wang, Zhi Qi

Article Affiliation:

Luyao Li

Abstract:

Epidemiological studies have demonstrated that vitamin C decreases the risk of stroke, which has generally been ascribed to its function as antioxidant and free radical scavenger. However, whether there is a defined molecular target for vitamin C on stroke is unknown. Utilizing middle cerebral artery occlusion (MCAO) in rats as a model for ischemic stroke, we demonstrated that long-term, low-dose administration of vitamin C prior to MCAO could exert significant neuroprotective effect on the brain damage. The long-term, low-dose vitamin C pre-treated rats had decreased brain infarct size and decreased neurological deficit score compared with the vehicle or single high dose pre-treated MCAO rats. Furthermore, electrophysiological experiments using patch clamp technique showed that vitamin C increased the whole-cell current of the large-conductance Ca-activated K(BK) channel. Moreover, vitamin C increased the open probability of the channel without change its amplitude. Importantly, blockade of the BKchannels abolished the neuroprotective effect of vitamin C on MCAO. Therefore, this study shows that long-term, low-dose pre-treatment with vitamin C could reduce MCAO-induced brain damage through activation of the BKchannels, suggesting that the BKchannel is a molecular target of vitamin C on stroke.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.