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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Ribes nigrum L. Prevents UVB-mediated Photoaging in Human Dermal Fibroblasts: Potential Antioxidant and Anti-inflammatory Activity.

Abstract Source:

Photochem Photobiol. 2018 May 16. Epub 2018 May 16. PMID: 29768726

Abstract Author(s):

Lu Li, Eunson Hwang, Hien T T Ngo, Seul A Seo, Pei Lin, Wei Gao, Ying Liu, Tae-Hoo Yi

Article Affiliation:

Lu Li

Abstract:

Black currants (Ribes nigrum L, RN) are known as a"super fruit"to possess for their many potential health benefits such as the alleviation of oxidative stress-related disorders. However, little skin photoaging-related research has been done on the use of this agent. In the present study, we investigated the protective effects of RN in UVB-irradiated human dermal fibroblasts (NHDFs).RN treatment in UVB-irradiated skin models alleviated UVB-mediated photoaging through several mechanisms: Treatment with RN downregulated MAPK-related signaling models, such as those of activation protein 1 (AP-1) and nuclear factor kappa B (NF-κB). In addition, phase II gene heme oxygenase-1 (HO-1) was modulated by the increase of nuclear factor erythroid 2-related factor 2 (Nrf2) in the nuclear, and finally, transforming growth factor TGF-β was upregulated in vitro. Further study indicated that UVB-induced production of MMP-1 and IL-6 could be inhibited by PD 98059 (an inhibitor of ERK) and SP600125 (an inhibitor of JNK). Thus, RN improved the expression of type I procollagen and inhibited UVB-induced MMP-1 and IL-6 secretion through inactivating MAPK cascades. Therefore, RN is a suitable target for further investigation as an anti-photoaging agent and may have applications in the skincare industry. This article is protected by copyright. All rights reserved.

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Depression: 21st Century Solutions + The Dark Side of Wheat

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