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Abstract Title:

In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction.

Abstract Source:

Reprod Toxicol. 2016 Sep 26 ;66:61-67. Epub 2016 Aug 26. PMID: 27686954

Abstract Author(s):

Arcangelo Barbonetti, Chiara Castellini, Noemi Di Giammarco, Gaetano Santilli, Sandro Francavilla, Felice Francavilla

Article Affiliation:

Arcangelo Barbonetti

Abstract:

As bisphenol A (BPA) exerts oxidative/pro-apoptotic effects in several cell types, we explored whether the in vitro exposure to BPA could affect human sperm integrity through the induction of pro-oxidative/apoptotic mitochondrial dysfunction. The exposure of motile sperm suspensions to scalar BPA concentrations for 4h produced a decrease in the mitochondrial membrane potential, starting from 300μM. It was associated with an increased mitochondrial generation of superoxide anion, caspase-9 and caspase-3 activation and motility decrement. Vitality decline was observed at BPA≥400μM. Twenty hours exposure to 300μM BPA, but not to lower concentrations, produced a significant loss in spermvitality associated with a complete sperm immobilization. Finally, 300μM BPA also produced a significant DNA oxidative damage, as revealed by the formation of oxidized base adduct 8-hydroxy-2'-deoxyguanosine. In conclusion, BPA affected human sperm integrity by inducing pro-oxidative/apoptotic mitochondrial dysfunction.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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