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Depression: 21st Century Solutions + The Dark Side of Wheat

Article Publish Status: FREE
Abstract Title:

Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa L.

Abstract Source:

Clin Mol Allergy. 2011 ;9(1):4. Epub 2011 Feb 8. PMID: 21303540

Abstract Author(s):

Eun-Hwa Sohn, Seon-A Jang, Haemi Joo, Sulkyoung Park, Se-Chan Kang, Chul-Hoon Lee, Sun-Young Kim

Article Affiliation:

Eun-Hwa Sohn

Abstract:

BACKGROUND: Atopic dermatitis is a chronic, allergic inflammatory skin disease that is accompanied by markedly increased levels of inflammatory cells, including eosinophils, mast cells, and T cells. Arctium lappa L. is a traditional medicine in Asia. This study examined whether a butanol extract of A. lappa (ALBE) had previously unreported anti-allergic or anti-inflammatory effects.

METHODS: This study examined the effect of ALBE on the release ofβ-hexosaminidase in antigen-stimulated-RBL-2H3 cells. We also evaluated the ConA-induced expression of IL-4, IL-5, mitogen-activated protein kinases (MAPKs), and nuclear factor (NF)-κB using RT-PCR, Western blotting, and ELISA in mouse splenocytes after ALBE treatment.

RESULTS: We observed significant inhibition ofβ-hexosaminidase release in RBL-2H3 cells and suppressed mRNA expression and protein secretion of IL-4 and IL-5 induced by ConA-treated primary murine splenocytes after ALBE treatment. Additionally, ALBE (100 μg/mL) suppressed not only the transcriptional activation of NF-κB, but also the phosphorylation of MAPKs in ConA-treated primary splenocytes.

CONCLUSIONS: These results suggest that ALBE inhibits the expression of IL-4 and IL-5 by downregulating MAPKs and NF-κB activation in ConA-treated splenocytes and supports the hypothesis that ALBE may have beneficial effects in the treatment of allergic diseases, including atopic dermatitis.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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