Abstract Title:

Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.

Abstract Source:

Future Microbiol. 2015 ;10(9):1433-45. Epub 2015 Sep 7. PMID: 26346930

Abstract Author(s):

Zhao-Fei Chen, Luo-Yan Ai, Ji-Lin Wang, Lin-Lin Ren, Ya-Nan Yu, Jie Xu, Hao-Yan Chen, Jun Yu, Min Li, Wen-Xin Qin, Xiong Ma, Nan Shen, Ying-Xuan Chen, Jie Hong, Jing-Yuan Fang

Article Affiliation:

Zhao-Fei Chen

Abstract:

AIMS: To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression.

MATERIALS & METHODS: The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were intervened by these two probiotics and the antitumor effects were examined by comparing the tumor incidence and detecting the inflammatory and immune-related markers.

RESULTS & CONCLUSIONS: C. butyricum and B. subtilis inhibited the proliferation of CRC cells, caused cell cycle arrest and promoted apoptosis. In vivo, these two probiotics inhibited the development of DMH-induced CRC. The molecular mechanism involved reduced inflammation and improved immune homeostasis. This work establishes a basis for the protective role of probiotics B. subtilis and C. butyricum in intestinal tumorigenesis.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.