n/a
Article Publish Status: FREE
Abstract Title:

Standardizedextract attenuates tau and stathmin gene expression in the melanoma cell line.

Abstract Source:

Iran J Basic Med Sci. 2017 Oct ;20(10):1178-1181. PMID: 29147495

Abstract Author(s):

Golnaz Vaseghi, Mohamad Javad Taki, Shaghayegh Haghjooy Javanmard

Article Affiliation:

Golnaz Vaseghi

Abstract:

Objectives: Metastasis is the main cause of death in patients with melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer metastasis. Here we have investigated the effect of a standardizedextract on cell migration and Tau and Stathmin gene expression in the melanoma cell line.

Materials and Methods: In the treatment group, melanoma (B1617) was treated 48 hr with various concentrations of standardizedextract. Cells with no treatment were considered as the control group, then study was followed by Quantitative RT-Real Time PCR assay. Relative gene expression was calculated by theΔΔct method. Migration assay was used to evaluate cancer metastasis.

Results: Tau and stathmin gene expression was significantly decreased compared to the control group. Cell migration was also significantly reduced compared to controls.

Conclusion: decreased tau and stathmin gene expression and cancer metastasis. The results may have some clinical relevance for the use of cannabis-based medicines in patients with metastatic melanoma.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.