Abstract Title:

Anti-HIV and vitamin C-synergized radical scavenging activity of cacao husk lignin fractions.

Abstract Source:

In Vivo. 2008 May-Jun;22(3):327-32. PMID: 18610744

Abstract Author(s):

Hiroshi Sakagami, Kazue Satoh, Haruka Fukamachi, Takeshi Ikarashi, Ai Shimizu, Kazuyoshi Yano, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima, Hideo Hasegawa, Akiko Nomura, Katsuaki Utsumi, Masaji Yamamoto, Yuuichi Maeda, Kenji Osawa

Article Affiliation:

Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan. sakagami@dent.meikai.ac.jp


Cacao husk lignin fractions, prepared by acid precipitation and 50% ethanol precipitation showed unexpectedly higher anti-human immunodeficiency virus (HIV) activity, as compared with the corresponding fractions from the cacao mass, amounting to the level comparable with that of popular anti-HIV compounds. The cacao husk lignin fractions also showed anti-influenza virus activity, but did not show antibacterial activity. The cacao husk lignin fractions synergistically enhanced the superoxide anion and hydroxyl radical scavenging activity of vitamin C. The cacao husk lignin fractions stimulated nitric oxide generation by mouse macrophage-like cells, to a level higher than that attained by lipopolysaccharide (LPS). The present study suggests the functionality of cacao husk lignin fractions as complementary alternative medicine.

Study Type : In Vitro Study

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