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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Effects of Cannabidiol on Morphine Conditioned Place Preference in Mice.

Abstract Source:

Planta Med. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28793355

Abstract Author(s):

James Roland Markos, Hannah M Harris, Waseem Gul, Mahmoud A ElSohly, Kenneth J Sufka

Article Affiliation:

James Roland Markos

Abstract:

This study sought to determine whether the cannabis constituent cannabidiol attenuates the development of morphine reward in the conditioned place preference paradigm. Separate groups of mice received either saline or morphine in combination with one of four doses of cannabidiol using three sets of drug/no-drug conditioning trials. After drug-place conditioning, morphine mice displayed robust place preference that was attenuated by 10 mg/kg cannabidiol. Further, when administered alone, this dose of cannabidiol was void of rewarding and aversive properties. The finding that cannabidiol blocks opioid reward suggests that this compound may be useful in addiction treatment settings.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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