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Abstract Title:

The cannabinoid 2 receptor agonistβ-caryophyllene modulates the inflammatory reaction induced by Mycobacterium bovis BCG by inhibiting neutrophil migration.

Abstract Source:

Inflamm Res. 2016 Nov ;65(11):869-879. Epub 2016 Jul 5. PMID: 27379721

Abstract Author(s):

Magaiver Andrade-Silva, Luana Barbosa Correa, André Luis Peixoto Candéa, Simone C Cavalher-Machado, Helene Santos Barbosa, Elaine Cruz Rosas, Maria G Henriques

Article Affiliation:

Magaiver Andrade-Silva

Abstract:

OBJECTIVE AND DESIGN: β-Caryophyllene (BCP) is a sesquiterpene that binds to the cannabinoid 2 (CB2) receptor and exerts anti-inflammatory effects. In this study, we investigated the anti-inflammatory effect of BCP and another CB2 agonist, GP1a in inflammatory experimental model induced by Mycobacterium bovis (BCG).

METHODS: C57Bl/6 mice were pretreated orally with BCP (0.5-50 mg/kg) or intraperitonealy with GP1a (10 mg/kg) 1 h before the induction of pleurisy or pulmonary inflammation by BCG. The direct action of CB2 agonists on neutrophils function was evaluated in vitro.

RESULTS: β-Caryophyllene (50 mg/kg) impaired BCG-induced neutrophil accumulation in pleurisy without affecting mononuclear cells or the production of TNF-α and CCL2/MCP-1. However, BCP inhibited CXCL1/KC, leukotriene B4 (LTB4), IL-12, and nitric oxide production. GP1a had a similar effect to BCP. Preincubation of neutrophils with BCP (10 µM) impaired chemotaxis toward LTB4 and adhesion to endothelial cells stimulated with TNF-α, and both, BCP and GP1a, impaired LTB4-induced actin polymerization.

CONCLUSION: These results suggest that the CB2 receptor may represent a new target for modulating the inflammatory reaction induced by mycobacteria.

Study Type : In Vitro Study

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