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Abstract Title:

A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells.

Abstract Source:

Int Immunopharmacol. 2008 May;8(5):732-40. Epub 2008 Feb 14. PMID: 18387516

Abstract Author(s):

Chi-Ya Lee, Shiaw-Pyng Wey, Mei-Hsiu Liao, Wei-Lun Hsu, Hsin-Ying Wu, Tong-Rong Jan

Abstract:

It has been shown that leukemia and glioma cells are sensitive to cannabidiol (CBD)-induced apoptosis, whereas primary monocytes and glia cells are relatively insensitive. In the current study, the cellular events and sensitivity to CBD-induced apoptosis between murine thymocytes and EL-4 thymoma cells were compared. Cannabidiol markedly induced apoptosis in a time- and concentration-related manner in both cells. The efficacy of CBD to induce apoptosis was comparable between the 2 types of T cells, whereas CBD induced apoptosis in thymocytes with a slightly greater potency than in EL4 cells. Time-course analyses revealed CBD-mediated apoptosis occurred earlier in EL-4 cells than that in thymocytes. An increased level of cellular reactive oxygen species (ROS) was detected in both cells with the peak response at 2 h post CBD treatment. Concordantly, CBD triggered a gradual diminishment in the cellular thiols. The presence of N-acetyl-L-cysteine (NAC), a precursor of glutathione, markedly attenuated the induction of apoptosis, and restored the diminished levels of cellular thiols. The results demonstrated that both thymocytes and EL-4 thymoma cells were susceptible to CBD-induced apoptosis and that ROS played a critical role in the apoptosis induction.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)

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Sayer Ji
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