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Abstract Title:

Antiviral activity of carrageenan on hepatitis A virus replication in cell culture.

Abstract Source:

Res Virol. 1991 Jul-Aug;142(4):261-70. PMID: 1665574

Abstract Author(s):

S Girond, J M Crance, H Van Cuyck-Gandre, J Renaudet, R Deloince

Article Affiliation:

Université J. Fourier, UFR Pharmacie, Service de Bactériologie-Virologie-Immunologie, La Tronche, France.

Abstract:

Sulphated polysaccharides such as iota-, lambda- and kappa-carrageenans showed a potent inhibitory effect on the replication of hepatitis A virus (HAV) in the human hepatoma cell line PLC/PRF/5. No cytotoxic effects were detected with concentrations of carrageenans up to 200 micrograms/ml. The selectivity indices of these substances, calculated as the ratio of the dose that reduced the number of viable cells to 50% (CD50) to the effective dose that inhibited 50% of viral antigen expression (ED50), were greater than 400 with iota-carrageenan, greater than 222 with lambda-carrageenan and greater than 10 with kappa-carrageenan. The selectivity index of ribavirin (reference substance) was only 5. The 3 types of carrageenans resulted in concentration-dependent reduction of HAV-antigen expression and HAV infectivity. lota-and lambda-carrageenan emerged, from the present study, as promising candidates for chemotherapy of acute hepatitis A.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(938) : AC(433)

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