Catabolism in host cells"fuels"the anabolic growth of cancer cells via energy transfer. - GreenMedInfo Summary
Power surge: supporting cells"fuel"cancer cell mitochondria.
Cell Metab. 2012 Jan 4 ;15(1):4-5. PMID: 22225869
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
An emerging paradigm in tumor metabolism is that catabolism in host cells"fuels"the anabolic growth of cancer cells via energy transfer. A study in Nature Medicine (Nieman et al., 2011) supports this; they show that triglyceride catabolism in adipocytes drives ovarian cancer metastasis by providing fatty acids as mitochondrial fuels.