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Article Publish Status: FREE
Abstract Title:

Vasorelaxant activity of extracts obtained from Apium graveolens: possible source for vasorelaxant molecules isolation with potential antihypertensive effect.

Abstract Source:

Asian Pac J Trop Biomed. 2013 Oct ;3(10):776-9. Epub 2013 Sep 4. PMID: 24075341

Abstract Author(s):

Vergara-Galicia Jorge, Jimenez-Ramirez Luis Ángel, Tun-Suarez Adrián, Aguirre-Crespo Francisco, Salazar-Gómez Anuar, Estrada-Soto Samuel, Sierra-Ovando Ángel, Hernandez-Nuñez Emmanuel

Article Affiliation:

Vergara-Galicia Jorge

Abstract:

OBJECTIVE: To investigate vasorelaxant effect of organic extracts from Apium graveolens (A. graveolens) which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.

METHODS: An ex vivo method was employed to assess the vasorelaxant activity. This consisted of using rat aortic rings with and without endothelium precontracted with norepinephrine.

RESULTS: All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A. graveolens. These results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium polarity. Also, our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from A. graveolens is mediated probably by calcium antagonism.

CONCLUSIONS: A. graveolens represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.

Study Type : Animal Study

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Sayer Ji
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