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Abstract Title:

Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage.

Abstract Source:

Lipids Health Dis. 2009;8:39. Epub 2009 Oct 5. PMID: 7694126

Abstract Author(s):

S K Abraham, L Sarma, P C Kesavan

Article Affiliation:

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

Abstract:

The mouse bone marrow micronucleus test was carried out to evaluate the possible role of the dietary constituents chlorogenic acid (CGA), curcumin (CR) and beta-carotene (BC) in modulating the in vivo chromosomal damage induced by gamma-radiation. The results obtained suggest that oral administration of CGA (50, 100 and 200 mg/kg b.w.), CR (5, 10 and 20 mg/kg b.w.) and BC (0.5 and 2.5 mg/kg b.w.) to mice can significantly reduce the frequencies of micronucleated polychromatic erythrocytes (Mn PCEs) induced by whole body exposure to gamma-radiation (1.15 Gy; 0.05 Gy/s). With CGA and CR, this effect was observed after a single administration either 2 h before or immediately after irradiation. However, with BC a 7-day feeding before irradiation was necessary to obtain a significant reduction in the incidence of Mn PCEs. The protective effects of CGA, CR and BC were observed in bone marrow cells sampled 24, 30 and 48 h after exposure to radiation.

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Sayer Ji
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Easy Turmeric recipes + The Dark Side of Wheat

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