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Depression: 21st Century Solutions + The Dark Side of Wheat

Article Publish Status: FREE
Abstract Title:

Choline and betaine intake and colorectal cancer risk in Chinese population: a case-control study.

Abstract Source:

PLoS One. 2015 ;10(3):e0118661. Epub 2015 Mar 18. PMID: 25785727

Abstract Author(s):

Min-Shan Lu, Yu-Jing Fang, Zhi-Zhong Pan, Xiao Zhong, Mei-Chun Zheng, Yu-Ming Chen, Cai-Xia Zhang

Article Affiliation:

Min-Shan Lu

Abstract:

BACKGROUND: Few studies have examined the association of choline and betaine intake with colorectal cancer risk, although they might play an important role in colorectal cancer development because of their role as methyl donors. The aim of this study was to examine the relationship between consumption of choline and betaine and colorectal cancer risk in a Chinese population.

METHODOLOGY/PRINCIPAL FINDINGS: A case-control study was conducted between July 2010 and December 2013 in Guangzhou, China. Eight hundred and ninety consecutively recruited colorectal cancer cases were frequency matched to 890 controls by age (5-year interval) and sex. Dietary information was assessed with a validated food frequency questionnaire by face-to-face interviews. The logistic regression model was used to estimate multivariate odds ratios (ORs) and 95% confidence intervals (CIs). Total choline intake was inversely associated with colorectal cancer risk after adjustment for various lifestyle and dietary factors. The multivariate-adjusted OR was 0.54 (95%CI = 0.37-0.80, Ptrend<0.01) comparing the highest with the lowest quartile. No significant associations were observed for betaine or total choline+betaine intakes. For choline-containing compounds, lower colorectal cancer risk was associated with higher intakes of choline from phosphatidylcholine, glycerophosphocholine and sphingomyelin but not for free choline and phosphocholine. The inverse association of total choline intake with colorectal cancer risk was observed in both men and women, colon and rectal cancer. These inverse associations were not modified by folate intake.

CONCLUSIONS: These results indicate that high intake of total choline is associated with a lower risk of colorectal cancer.

Study Type : Human Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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