Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients. - GreenMedInfo Summary

Abstract Title:

Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS.

Abstract Source:

Neurology. 2005 Dec 13;65(11):1834-6. PMID: 16344537

Abstract Author(s):

K L Ferrante, J Shefner, H Zhang, R Betensky, M O'Brien, H Yu, M Fantasia, J Taft, M F Beal, B Traynor, K Newhall, P Donofrio, J Caress, C Ashburn, B Freiberg, C O'Neill, C Paladenech, T Walker, A Pestronk, B Abrams, J Florence, R Renna, J Schierbecker, B Malkus, M Cudkowicz

Article Affiliation:

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. [email protected]

Abstract:

An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months.

Article Published Date : Dec 13, 2005
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(2309) : AC(397)
Diseases : Amyotrophic Lateral Sclerosis : CK(789) : AC(205)
Pharmacological Actions : Antioxidants : CK(21528) : AC(13231), Neuroprotective Agents : CK(10404) : AC(6995)

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Key Research Topics

Substance

Coenzyme Q10

Disease

Amyotrophic Lateral Sclerosis

Pharmacological Actions

Antioxidants
Neuroprotective Agents

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