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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis.

Abstract Source:

Am J Epidemiol. 2014 Oct 15 ;180(8):763-75. Epub 2014 Aug 24. PMID: 25156996

Abstract Author(s):

Alessio Crippa, Andrea Discacciati, Susanna C Larsson, Alicja Wolk, Nicola Orsini

Article Affiliation:

Alessio Crippa

Abstract:

Several studies have analyzed the relationship between coffee consumption and mortality, but the shape of the association remains unclear. We conducted a dose-response meta-analysis of prospective studies to examine the dose-response associations between coffee consumption and mortality from all causes, cardiovascular disease (CVD), and all cancers. Pertinent studies, published between 1966 and 2013, were identified by searching PubMed and by reviewing the reference lists of the selected articles. Prospective studies in which investigators reported relative risks of mortality from all causes, CVD, and all cancers for 3 or more categories of coffee consumption were eligible. Results from individual studies were pooled using a random-effects model. Twenty-one prospective studies, with 121,915 deaths and 997,464 participants, met the inclusion criteria. There was strong evidence of nonlinear associations between coffee consumption and mortality for all causes and CVD (P for nonlinearity<0.001). The largest risk reductions were observed for 4 cups/day for all-cause mortality (16%, 95% confidence interval: 13, 18) and 3 cups/day for CVD mortality (21%, 95% confidence interval: 16, 26). Coffee consumption was not associated with cancer mortality. Findings from this meta-analysis indicate that coffee consumption is inversely associated with all-cause and CVD mortality.

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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