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Abstract Title:

Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.

Abstract Source:

Antiviral Res. 2009 Aug;83(2):186-90. Epub 2009 May 20. PMID: 19463857

Abstract Author(s):

Gui-Feng Wang, Li-Ping Shi, Yu-Dan Ren, Qun-Fang Liu, Hou-Fu Liu, Ru-Jun Zhang, Zhuang Li, Feng-Hua Zhu, Pei-Lan He, Wei Tang, Pei-Zhen Tao, Chuan Li, Wei-Min Zhao, Jian-Ping Zuo

Article Affiliation:

Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China.

Abstract:

Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.

Study Type : In Vitro Study

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Sayer Ji
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