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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Coffee and cancer risk: A meta-analysis of prospective observational studies.

Abstract Source:

Sci Rep. 2016 Sep 26 ;6:33711. Epub 2016 Sep 26. PMID: 27665923

Abstract Author(s):

Anqiang Wang, Shanshan Wang, Chengpei Zhu, Hanchun Huang, Liangcai Wu, Xueshuai Wan, Xiaobo Yang, Haohai Zhang, Ruoyu Miao, Lian He, Xinting Sang, Haitao Zhao

Article Affiliation:

Anqiang Wang

Abstract:

Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg's and egger's test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48-0.99, I(2) = 73.4%, P = 0.044), 0.87 (95% CI = 0.78-0.96, I(2) = 28.4%, P = 0.007), 0.46 (95% CI = 0.37-0.57, I(2) = 0%, P = 0), 0.89 (95% CI = 0.84-0.93, I(2) = 30.3%, P = 0.003), 0.73 (95% CI = 0.67-0.80, I(2)  = 0%, P = 0) and 0.89 (95% CI = 0.80-0.99, I(2)  = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26-3.75, I(2)  = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67-0.79 for liver cancer, RR = 0.97, 95% CI = 0.96-0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85-0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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