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Abstract Title:

Investigation of a complex plant extract for mild to moderate erectile dysfunction in a randomized, double-blind, placebo-controlled, parallel-arm study.

Abstract Source:

BJU Int. 2010 Feb 22. Epub 2010 Feb 22. PMID: 20184576

Abstract Author(s):

Andrea Ledda, Gianni Belcaro, Maria R Cesarone, Mark Dugall, Frank Schönlau

Article Affiliation:

Irvine Vascular Laboratories and Physiology, Department of Biomedical Sciences, Gabriele D'Annunzio University, Chieti-Pescara, Italy, and Horphag Research UK Ltd, South Kensington, London, UK.

Abstract:

Study Type - Therapy (RCT) Level of Evidence 1b OBJECTIVE To assess the effects of a complex plant extract (Prelox(R), a formulation of pine bark extract and l-arginine aspartate; Horphag Research UK Ltd, London, UK) on erectile dysfunction (ED) in men, as sexual desire typically persists in ageing men, while their erectile and endothelial function gradually declines. PATIENTS AND METHODS In this double-blind, placebo-controlled study we assessed the effects of Prelox in 124 patients (aged 30-50 years) with moderate ED over an investigational period of 6 months. The International Index Of Erectile Function (IIEF) was used to quantify changes in sexual function. RESULTS The erectile domain of the IIEF (questions 1-5 plus 15) improved with Prelox from a baseline mean (sd) score of 15.2 (6.6) to 25.2 (2.1) after 3 months and 27.1 (2.1) after 6 months of treatment. In the placebo group there was an increase from a baseline score of 15.1 (7.0) to 19.1 (3.0) and 19.0 (3.1) after 3 and 6 months, respectively. The effects with Prelox were statistically significant compared with placebo (P<0.05). Mean (sd) total plasma testosterone levels increased significantly from 15.9 (2.3) to 18.9 (2.6) nmol/L (P<0.05) after 6 months with Prelox, compared to an increase from 16.9 (2.4) to 17.3 (2.3) nmol/L in the placebo group. CONCLUSION This study shows that Prelox is effective for improving erectile function, and that this effect persists on continuous therapy for up to 6 months. Moreover, there is some evidence that erectile function continues to improve the longer the therapy is used.

Study Type : Human Study

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Sayer Ji
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