Abstract Title:

Quercetin Mediatesβ-Catenin in Pancreatic Cancer Stem-Like Cells.

Abstract Source:

Pancreas. 2015 Aug 17. Epub 2015 Aug 17. PMID: 26284537

Abstract Author(s):

Caineng Cao, Lixin Sun, Wenxiu Mo, Lichao Sun, Jingwei Luo, Zhihua Yang, Yuliang Ran

Article Affiliation:

Caineng Cao

Abstract:

OBJECTIVE: The aim of this study is to explore how quercetin interacts with pancreatic cancer stem-like cells and the mechanism underlying the effective quercetin-mediated suppression.

METHODS: A model of pancreatic cancer stem-like cells was generated by using a sphere formation culture system. A comparative analysis was performed between the parent cells and pancreatic cancer stem-like cells with a related treatment strategy focusing on cancer stem cell (CSC) properties and drug-resistance-related mechanisms in vitro.

RESULTS: Our data show that pancreatic cancer stem-like cells have greater resistance to gemcitabine and stronger CSC properties compared with the parent cells. In contrast to the pancreatic cancer stem-like cells, overexpression ofβ-catenin was observed in the parent cells. Quercetin suppressed proliferation, invasion and self-renewal capacity, and CSC surface markers expression, with alterations of β-catenin in pancreatic cancer stem-like cells. The combination of quercetin and gemcitabine can reduce tumor growth and decrease drug resistance in pancreatic cancer.

CONCLUSIONS: β-Catenin plays an important role in maintenance and progression of pancreatic cancer. Targeting β-catenin using quercetin combined with gemcitabine may be a treatment strategy to improve prognosis in patients with pancreatic cancer.

Study Type : In Vitro Study

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