Compounds found within the tree Casesalpinia sappan have neuraminidase inhibitory activity superior to osestamivir acid (Tamiflu) and Ribavirin. - GreenMedInfo Summary

Abstract Title:

In vitro anti-influenza viral activities of constituents from Caesalpinia sappan.

Abstract Source:

Planta Med. 2009 Mar;75(4):337-9. Epub 2009 Jan 15. PMID: 19148862

Abstract Author(s):

Ai-Lin Liu, Shi-Hui Shu, Hai-Lin Qin, Simon Ming Yuen Lee, Yi-Tao Wang, Guan-Hua Du

Abstract:

Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 microg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 microg/mL, respectively.

Article Published Date : Mar 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Sappanwood : CK(1) : AC(1)

Diseases : Influenza : CK(1407) : AC(361), Influenza A : CK(534) : AC(198)

Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1615), Neurominidase Inhibitor : CK(20) : AC(23)

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Compounds found within the tree Casesalpinia sappan have neuraminidase inhibitory activity superior to osestamivir acid (Tamiflu) and Ribavirin. - GreenMedInfo Summary

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