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Abstract Title:

Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.

Abstract Source:

Front Pharmacol. 2017 ;8:469. Epub 2017 Jul 25. PMID: 28790915

Abstract Author(s):

Sadia Naz, Umar Farooq, Ajmal Khan, Haroon Khan, Nasiara Karim, Rizwana Sarwar, Javid Hussain, Abdur Rauf

Article Affiliation:

Sadia Naz

Abstract:

Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (2) based on spectroscopic data through IR, UV, (1)H-NMR, (13)C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds 1 and 2 were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.

Study Type : Animal Study

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Sayer Ji
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