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Abstract Title:

Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis: a pilot study.

Abstract Source:

Isr Med Assoc J. 2011 Aug ;13(8):474-9. PMID: 21910371

Abstract Author(s):

Alexandra Balbir-Gurman, Bianca Fuhrman, Yolanda Braun-Moscovici, Doron Markovits, Michael Aviram

Article Affiliation:

Rheumatology Unit, Rambam Health Care Campus, Haifa, Israel. a_balbir@rambam.health.gov.il

Abstract:

BACKGROUND: Pomegranate extract (POMx) consumption has been shown to reduce the incidence and severity of collagen-induced arthritis in mice.

OBJECTIVES: To investigate whether pomegranate consumption affects disease activity in patients with rheumatoid arthritis (RA), in relation to their serum oxidative status.

METHODS: In this pilot 12 week open-labeled study eight patients with active RA consumed POMx (10 ml/day) for 12 weeks. Patients' joint status and serum oxidative status (lipid peroxidation, total thiols group, paraoxonase 1 activity) were evaluated at baseline and at week 12.

RESULTS: Six patients completed the study. POMx consumption significantly (P<0.02) reduced the composite Disease Activity Index (DAS28) by 17%, which could be related mostly to a significant (P<0.005) reduction in the tender joint count (by 62%). These results were associated with a significant (P<0.02) reduction in serum oxidative status and a moderate but significant (P<0.02) increase in serum high density lipoprotein-associated paraoxonase 1 (PON1) activity. The addition of POMx to serum from RA patients reduced free radical-induced lipid peroxidation by up to 25%.

CONCLUSIONS: The pomegranate consumption reduced DAS28 in RA patients, and this effect could be related to the antioxidative property of pomegranates. Dietary supplementation with pomegranates may be a useful complementary strategy to attenuate clinical symptoms in RA patients.

Study Type : Human Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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