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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Crocin promotes non-rapid eye movement sleep in mice.

Abstract Source:

Mol Nutr Food Res. 2012 Feb ;56(2):304-8. Epub 2011 Oct 28. PMID: 22038919

Abstract Author(s):

Mika Masaki, Kosuke Aritake, Hiroyuki Tanaka, Yukihiro Shoyama, Zhi-Li Huang, Yoshihiro Urade

Article Affiliation:

Mika Masaki

Abstract:

Crocus sativus L. (saffron) has been traditionally used for the treatment of insomnia and other diseases of the nervous systems. Two carotenoid pigments, crocin and crocetin, are the major components responsible for the various pharmacological activities of C. sativus L. In this study, we examined the sleep-promoting activity of crocin and crocetin by monitoring the locomotor activity and electroencephalogram after administration of these components to mice. Crocin (30 and 100 mg/kg) increased the total time of non-rapid eye movement (non-REM) sleep by 60 and 170%, respectively, during a 4-h period from 20:00 to 24:00 after its intraperitoneal administration at a lights-off time of 20:00. Crocetin (100 mg/kg) also increased the total time of non-REM sleep by 50% after the administration. These compounds did not change the amount of REM sleep or show any adverse effects, such as rebound insomnia, after the induction of sleep.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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