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Abstract Title:

The Mechanism of Protective Effect of Crocin against Liver Mitochondrial Toxicity Caused by Arsenic III.

Abstract Source:

Toxicol Mech Methods. 2017 Aug 16:1-34. Epub 2017 Aug 16. PMID: 28812436

Abstract Author(s):

Bahareh Sadat Yousefsani, Jalal Pourahmad, Hossein Hosseinzadeh

Article Affiliation:

Bahareh Sadat Yousefsani

Abstract:

In this study, we want to understand whether crocin could prevent mitochondrial damage caused by As III. For this purpose, we determined different mitochondrial toxicity endpoints caused by As III. We evaluated mitochondrial ROS formation, lipid peroxidation, mitochondrial membrane potential collapse, mitochondrial outer membrane integrity and cytochrome c release. Our results showed that pretreatment with crocin at a concentration of 25µg/ml significantly (P < 0.001) reduced As III induced mitochondrial ROS formation, lipid peroxidation, mitochondrial membrane potential collapse and mitochondrial swelling. Crocin also protected the mitochondria by decreasing the mitochondrial outer membrane damage that leads to reduce the amount of cytochrome c releaseThese results demonstrated that crocin is a promising antidotal candidate by ameliorating As III induced oxidative stress though mitochondrial targeting.

Study Type : In Vitro Study

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Sayer Ji
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