Curcumin bioconjugates may make suitable antiviral agents. - GreenMedInfo Summary
Design and development of curcumin bioconjugates as antiviral agents.
Nucleic Acids Symp Ser (Oxf). 2008(52):599-600. PMID: 18776522
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.
A number of curcumin bioconjugates with fatty acid, dipeptide and folic acid, viz. di-O-decanoyl curcumin (2), di-O-tryptophanylphenylalanine curcumin (3), di-O-bis-(gamma, gamma)folyl curcumin (4), C(4)-ehyl-O-gamma-folyl curcumin (5) and 4-O-ethyl-O-gamma-folyl curcumin (6) have been synthesized. Conjugates 2-6 have shown good antiviral property with EC(50) ranging between 0.019-0.105 microM against a wide range of viruses, like HIV, HSV, VSV and many others.