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Abstract Title:

Evaluation of antidepressant like activity of curcumin and its combination with fluoxetine and imipramine: an acute and chronic study.

Abstract Source:

Acta Pol Pharm. 2011 Sep-Oct;68(5):769-75. PMID: 21928724

Abstract Author(s):

Jayesh Sanmukhani, Ashish Anovadiya, Chandrabhanu B Tripathi

Article Affiliation:

Department of Pharmacology, Government Medical College, Bhavnagar - 364001, Gujarat, India.

Abstract:

Curcumin is the active ingredient of commonly used spice Curuma longa Linn. In the present study, the antidepressant like activity of curcumin and its combination with fluoxetine and imipramine was studied in acute model (three doses 24, 5 and 1 h before test) of forced swimming test (FST) in glass jar and tail suspension test (TST) in mice and in chronic model (14 day study) of FST with water wheel in rats. All the tests were carried out in the following seven groups (n = 6 in each group), drugs being given orally (doses for mice): Group 1 (vehicle), group 2 (curcumin 50 mg/kg), group 3 (curcumin 100 mg/kg), group 4 (fluoxetine 20 mg/kg), group 5 (imipramine 15 mg/kg), group 6 (curcumin 100 mg/kg plus fluoxetine 20 mg/kg) and group 7 (curcumin 100 mg/kg plus imipramine 15 mg/kg). Equivalent doses for rats were used. Both the acute model of FST and TST, and the chronic model of FST with water wheel showed significant antidepressant like activity of curcumin in 100 mg/kg dose as compared to vehicle control (p<0.05). The effect of curcumin (100 mg/kg) was similar to that of fluoxetine and imipramine (p>0.05) but its addition to fluoxetine and imipramine did not improve their antidepressant activity (p>0.05). Curcumin increased both the swimming and climbing behavior in FST, thus its antidepressant like activity could be due to an increase in serotonin, norepinephrine and dopamine levels in the brain. Curcumin can be a useful antidepressant especially in cases which respond to drugs having mixed effects on serotonin and catecholamines levels in the brain.

Study Type : Animal Study

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The antidepressant benefit of curcumin



There's no doubt.  I've been taking curcumin for at least 4 months now and I feel great.  I don't feel tired or depressed like I felt before starting it.  I just didn't feel like doing to much around the house and wasn't interested in doing things with the family and had completely stopped exercising.  Now I enjoy doing a lot of thing that used to bore me so I really do feel that the curcumin is as good as any antidepressant on the market plus it's natural so no side effects.

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