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Abstract Title:

Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats.

Abstract Source:

Neurotoxicology. 2010 Sep;31(5):533-9. Epub 2010 May 11. PMID: 20466022

Abstract Author(s):

Rajesh S Yadav, Rajendra K Shukla, Madhu Lata Sankhwar, Devendra K Patel, Reyaz W Ansari, Aditya B Pant, Fakhrul Islam, Vinay K Khanna

Article Affiliation:

Indian Institute of Toxicology Research (A Constituent Laboratory of Council of Scientific and Industrial Research, New Delhi), Post Box 80, MG Marg, Lucknow 226001, India.

Abstract:

Our recent studies have shown that arsenic-induced neurobehavioral toxicity is protected by curcumin by modulating oxidative stress and dopaminergic functions in rats. In addition, the neuroprotective effect of curcumin has been investigated on arsenic-induced alterations in biogenic amines, their metabolites and nitric oxide (NO), which play an important role in neurotransmission process. Decrease in the levels of dopamine (DA, 28%), norepinephrine (NE, 54%), epinephrine (EPN, 46%), serotonin (5-HT, 44%), 3,4-dihydroxyphenylacetic acid (DOPAC, 20%) and homovanillic acid (HVA, 31%) in corpus striatum; DA (51%), NE (22%), EPN (47%), 5-HT (25%), DOPAC (34%) and HVA (41%) in frontal cortex and DA (35%), NE (35%), EPN (29%), 5-HT (54%), DOPAC (37%) and HVA (46%) in hippocampus, observed in arsenic (sodium arsenite, 20 mg/kg body weight, p.o., 28 days) treated rats exhibited a trend of recovery in rats simultaneously treated with arsenic and curcumin (100 mg/kg body weight, p.o., 28 days). Increased levels of NO in corpus striatum (2.4-fold), frontal cortex (6.1-fold) and hippocampus (6.2-fold) in arsenic-treated rats were found decreased in rats simultaneously treated with arsenic and curcumin. It is evident that curcumin modulates levels of brain biogenic amines and NO in arsenic-exposed rats and these results further strengthen its neuroprotective efficacy.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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