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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells.

Abstract Source:

Biochim Biophys Acta. 1994 Dec 30;1224(3):597-600. PMID: 7803521

Abstract Author(s):

L Korutla, R Kumar

Article Affiliation:

Department of Medicine, Pennsylvania State University College of Medicine, Hershey 17033.

Abstract:

We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells. The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors. The observed early effects of Curcumin were mediated via a cellular mechanism(s), and preceded the period when inhibition of cell growth occurred.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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