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Abstract Title:

Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1.

Abstract Source:

Oncol Rep. 2006 Jun;15(6):1557-62. PMID: 16685395

Abstract Author(s):

Moon-Kyoung Bae, Se-Hee Kim, Joo-Won Jeong, You Mie Lee, Hae-Sun Kim, Su-Ryun Kim, Il Yun, Soo-Kyung Bae, Kyu-Won Kim

Article Affiliation:

College of Dentistry, Pusan National University, Busan 602-739, Korea.

Abstract:

Hypoxia-inducible factor-1 (HIF-1) has a central role in cellular responses to hypoxia, including the transcriptional activation of a number of genes involved in angiogenesis in tumors. We found that curcumin, a natural, biologically active compound isolated from the commonly used spice turmeric, significantly decreases hypoxia-induced HIF-1alpha protein levels in HepG2 hepatocellular carcinoma cells. Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor. Curcumin also blocked hypoxia-stimulated angiogenesis in vitro and down-regulated HIF-1alpha and VEGF expression in vascular endothelial cells. These findings suggest that curcumin may play pivotal roles in tumor suppression via the inhibition of HIF-1alpha-mediated angiogenesis.

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Sayer Ji
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