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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents.

Abstract Source:

Biosci Biotechnol Biochem. 2010;74(1):185-7. Epub 2010 Jan 7. PMID: 20057137

Abstract Author(s):

Issei Dairaku, Yunkyung Han, Noriyuki Yanaka, Norihisa Kato

Article Affiliation:

Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan.

Abstract:

Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guanine nucleotides, is a therapeutic target for anticancer and antiviral agents. Among the 15 different polyphenols examined, curcumin was found to have an inhibitory effect on the IMPDH activity in both a competitive and uncompetitive manner and to suppress the cellular GTP level in HT-29 colon carcinoma cells.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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