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Abstract Title:

Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence.

Abstract Source:

Int J Mol Med. 2000 Nov;6(5):521-6. PMID: 11029517

Abstract Author(s):

E Skrzypczak-Jankun, N P McCabe, S H Selman, J Jankun

Article Affiliation:

Instrumentation Center, College of Art and Sciences, The University of Toledo, Toledo, OH 43606, USA.

Abstract:

Many lipoxygenase inhibitors including curcumin are currently being studied for their anti-carcinogenic properties. Curcumin is a naturally occurring polyphenolic phytochemical isolated from the powdered rhizome of the plant Curcuma longa that possesses anti-inflammatory properties and inhibits cancer formation in mice. Recently it was shown that the soybean lipoxygenase L1 catalyzed the oxygenation of curcumin and that curcumin can act as a lipoxygenase substrate. In the current study, we investigated the fate of curcumin when used as a soybean lipoxygenase L3 substrate. By use of X-ray diffraction and mass spectrometry, we found an unoccupied electron mass that appears to be an unusual degradation product of curcumin (4-hydroxyperoxy-2-methoxyphenol) located near the soybean L3 catalytic site. Understanding how curcumin inhibits lipoxygenase may help in the development of novel anti-cancer drugs used for treatment where lipoxygenases are involved.

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Sayer Ji
Founder of GreenMedInfo.com

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Easy Turmeric recipes + The Dark Side of Wheat

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