Abstract Title:

Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression.

Abstract Source:

Nutr Metab Cardiovasc Dis. 2010 Feb;20(2):125-32. Epub 2009 May 17. PMID: 19447587

Abstract Author(s):

Y-M Yu, H-C Lin

Article Affiliation:

Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan, Taiwan. [email protected]

Abstract:

BACKGROUND AND AIM: The migration of vascular smooth muscle cells from the tunica media to the subendothelial region is a key event in the development of atherosclerosis. Curcumin, which is consumed daily by millions of people, is a polyphenol derived from the plant Curcuma longa. In this study, we investigated the effects of curcumin on tumor necrosis factor-alpha (TNF-alpha)-induced cell migration, the formation of intracellular reactive oxygen species (ROS), the translocation of nuclear factor-kappaB (NFkappaB) and the activation and expression of MMP-9 in human aortic smooth muscle cells (HASMCs).

METHODS AND RESULTS: The Matrigel migration assay showed that curcumin (10 and 20 micromol/l) effectively inhibited TNF-alpha-induced migration of HASMCs as compared with the control group. To explain this inhibitory effect, MMP-9 was assayed by gelatin zymography and Western blot. The results indicated that curcumin inhibited MMP-9 activity and expression. Furthermore, the production of ROS and the nuclear translocation of NF-kappaB p50 and p65 induced by TNF-alpha were dose-dependently suppressed by curcumin pretreatment.

CONCLUSION: These results indicate that curcumin has anti-inflammatory properties and may prevent the migration of HASMCs by suppressing MMP-9 expression through down-regulation of NF-kappaB.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.