Abstract Title:

Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria?

Abstract Source:

Antioxid Redox Signal. 2007 Mar;9(3):399-408. PMID: 17184173

Abstract Author(s):

Rajeswara Babu Mythri, Balusamy Jagatha, Nityananda Pradhan, Julie Andersen, M M Srinivas Bharath

Article Affiliation:

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

Abstract:

Selective damage of mitochondrial complex I within the dopaminergic neurons of the substantia nigra is the central event during Parkinson disease. Peroxynitrite is one of the important free radicals probably mediating complex I damage. Peroxynitrite inhibits brain complex I mainly by 3-nitrotyrosine and nitrosothiol formation, but how these modifications alter the structure-function relation of complex I is unclear. Curcumin pretreatment protects brain mitochondria against peroxynitrite in vitro by direct detoxification and prevention of 3-nitrotyrosine formation and in vivo by elevation of total cellular glutathione levels. These results suggest a potential therapeutic role for curcumin against nitrosative stress in neurological disorders.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.