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Abstract Title:

Curcumin suppresses PPARdelta expression and related genes in HT-29 cells.

Abstract Source:

World J Gastroenterol. 2009 Mar 21;15(11):1346-52. PMID: 19294764

Abstract Author(s):

Jin-Bo Wang, Li-Li Qi, Shui-Di Zheng, Heng-Zheng Wang, Tian-Xing Wu

Article Affiliation:

Department of Chemistry, College of Science, Zhejiang University, Hanzhou 310027, Zhejiang Province, China.

Abstract:

AIM: To investigate the effects of curcumin on the expression of peroxisome proliferator-activated receptordelta (PPARdelta) and related genes in HT-29 cells.

METHODS: HT-29 cells were treated with curcumin (0-80 micromol/L) for 24 h. The effects of curcumin on the morphology of HT-29 cells were studied by Hoechst 33342 staining. The activity of caspase-3 was determined using DEVD-pNA as substrate. The levels of peroxisome PPARdelta, 14-3-3epsilon and vascular endothelial growth factor (VEGF) in HT-29 cells were determined by Western blotting analysis and their mRNA expression was determined by real-time quantitative RT-PCR.

RESULTS: Treatment with 10-80 micromol/L curcumin induced typical features of apoptosis and activated the caspase-3 in HT-29 cells. The expression of PPARdelta, 14-3-3epsilon and VEGF was reduced and the activity of beta-catenin/Tcf-4 signaling was inhibited by curcumin treatment.

CONCLUSION: Curcumin can induce apoptosis of HT-29 cells and down-regulate the expression of PPARdelta, 14-3-3epsilon and VEGF in HT-29.

Study Type : In Vitro Study

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