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Abstract Title:

A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes.

Abstract Source:

Acta Diabetol. 2017 04 ;54(4):361-365. Epub 2016 Dec 30. PMID: 28039583

Abstract Author(s):

Anna Rita Maurizi, Marika Menduni, Rossella Del Toro, Shadi Kyanvash, Daria Maggi, Chiara Guglielmi, Angelo Lauria Pantano, Giuseppe Defeudis, Elvira Fioriti, Silvia Manfrini, Paolo Pozzilli

Article Affiliation:

Anna Rita Maurizi

Abstract:

AIMS: To improve insulin sensitivity, insulin-sensitizing drugs such as metformin are commonly used in overweight and obese T1D patients. Similarly to metformin, D-chiro-inositol (DCI), as putative mediator of intracellular insulin action, can act as insulin sensitizer. The aim of this pilot study was to evaluate the hypothesis that DCI plus folic acid may improve glucose control reducing insulin resistance in overweight or obese T1D patients.

METHODS: A 24-week randomized control trial was carried out in 26 overweight or obese T1D patients, undergoing intensive insulin therapy. Patients were randomized to 1 g DCI plus 400 mcg folic acid once daily (treated group) or to 400 mcg folic acid only once daily (control group). The primary end point was to evaluate the efficacy of DCI on metabolic control as assessed by HbA1c. As secondary endpoints, BMI and insulin requirement (IR) were evaluated. Paired ttest (two tailed) and analysis of variance were used to evaluate differences in HbA1c, BMI and IR at different time points.

RESULTS: A significant reduction in HbA1c levels in treated group versus control group (7.5% ± 0.9 vs. 7.9% ± 1.7, respectively, p < 0.05) was observed. However, no significant reduction in BMI and IR was observed [(BMI 25.7 ± 2.8 vs. 26.7 ± 1.0, respectively, p NS); (IR 0.52 ± 0.26 vs. 0.52 ± 0.19, respectively, p NS)].

CONCLUSIONS: This trial demonstrated for the first time that DCI plus folic acid oral supplementation can improve metabolic control in overweight T1D patients. CLINICALTRIAL.

GOV ID: NCT02730949.

Study Type : Human Study

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