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Abstract Title:

Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats.

Abstract Source:

World J Gastroenterol. 2005 Jan 28;11(4):597-9. PMID: 15641154

Abstract Author(s):

Sang-Wan Seo, Hyun-Na Koo, Hyo-Jin An, Kang-Beom Kwon, Byung-Cheal Lim, Eun-A Seo, Do-Gon Ryu, Goo Moon, Hong-Yeoul Kim, Hyung-Min Kim, Seung-Heon Hong

Abstract:

AIM: Taraxacum officinale (TO) has been frequently used as a remedy for inflammatory diseases. The aim of this study was to investigate the effect of TO on cholecystokinin (CCK)-octapeptide-induced acute pancreatitis in rats. METHODS: TO at 10 mg/kg was orally administered, followed by 75 microg/kg CCK octapeptide injected subcutaneously three times after 1, 3 and 5 h. This whole procedure was repeated for 5 d. We determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60 and HSP72, and the secretion of pro-inflammatory cytokines. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally-induced pancreatitis. RESULTS: TO significantly decreased the pancreatic weight/body weight ratio in CCK octapeptide-induced acute pancreatitis. TO also increased the pancreatic levels of HSP60 and HSP72. Additionally, the secretion of IL-6 and TNF-alpha decreased in the animals treated with TO. CONCLUSION: TO may have a protective effect against CCK octapeptide-induced acute pancreatitis.

Study Type : Animal Study

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Sayer Ji
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