Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide. - GreenMedInfo Summary

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Abstract Title:

Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide.

Abstract Source:

Small. 2009 Jul ;5(13):1562-8. PMID: 19296557

Abstract Author(s):

Yu Hoshino, Takeo Urakami, Takashi Kodama, Hiroyuki Koide, Naoto Oku, Yoshio Okahata, Kenneth J Shea

Article Affiliation:

Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA. yhoshino@uci.edu

Abstract:

Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.

Article Published Date : Jul 01, 2009
Study Type : Review
Additional Links
Additional Keywords : Mad Science : CK(61) : AC(24), Plastic Antibodies : CK(5) : AC(4), Transhumanism : CK(3) : AC(3)
Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

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