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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Dietary Broccoli Impacts Microbial Community Structure and Attenuates Chemically Induced Colitis in Mice in an Ah receptor dependent manner.

Abstract Source:

J Funct Foods. 2017 Oct ;37:685-698. Epub 2017 Sep 1. PMID: 29242716

Abstract Author(s):

Troy D Hubbard, Iain A Murray, Robert G Nichols, Kaitlyn Cassel, Michael Podolsky, Guray Kuzu, Yuan Tian, Phillip Smith, Mary J Kennett, Andrew D Patterson, Gary H Perdew

Article Affiliation:

Troy D Hubbard

Abstract:

Consumption of broccoli mediates numerous chemo-protective benefits through the intake of phytochemicals, some of which modulate aryl hydrocarbon receptor (AHR) activity. Whether AHR activation is a critical aspect of the therapeutic potential of dietary broccoli is not known. Here we administered isocaloric diets, with or without supplementation of whole broccoli (15% w/w), to congenic mice expressing the high-affinity Ahrb/b or low-affinity Ahrd/d alleles, for 24 days and examined the effects on AHR activity, intestinal microbial community structure, inflammatory status, and response to chemically induced colitis. Cecal microbial community structure and metabolic potential were segregated according to host dietary and AHR status. Dietary broccoli associated with heightened intestinal AHR activity, decreased microbial abundance of the family Erysipelotrichaceae, and attenuation of colitis. In summary, broccoli consumption elicited an enhanced response in ligand-sensitive Ahrb/b mice, demonstrating that in part the beneficial aspects of dietary broccoli upon intestinal health are associated with heightened AHR activity.

Study Type : Animal Study
Additional Links
Additional Keywords : Microbiota : CK(396) : AC(101)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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