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Abstract Title:

Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytes.

Abstract Source:

Arch Biochem Biophys. 2010 Mar 1;495(1):49-55. Epub 2009 Dec 21. PMID: 20026030

Abstract Author(s):

Sung Nim Han, Eunice Pang, Jean-Marc Zingg, Simin Nikbin Meydani, Mohsen Meydani, Angelo Azzi

Article Affiliation:

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, South Korea.

Abstract:

Mice were supplemented with low and high doses of natural and synthetic vitamin E, T cells from the spleen isolated and stimulated with plate-bound anti-CD3 and soluble anti-CD28, and gene expression changes assessed by gene array experiments. The data obtained indicate significant qualitative and quantitative differences between the two vitamin forms in regulating gene expression in response to T-cell stimulation. Marker genes have been found whose expression can be considered significant in establishing the level of, and response to vitamin E for both natural and synthetic vitamin E supplementation; unique markers for synthetic vitamin E supplementation and unique markers for natural vitamin E supplementation have been identified.

Study Type : In Vitro Study
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Sayer Ji
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