Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

n/a
Abstract Title:

Docosapentaenoic acid and Docosahexaenoic acid positively associate with insulin sensitivity in rats fed high-fat and high-fructose diets.

Abstract Source:

J Diabetes. 2016 Nov 8. Epub 2016 Aug 8. PMID: 27860326

Abstract Author(s):

Jiung-Pang Huang, Mei-Ling Cheng, Cheng-Yu Hung, Chao-Hung Wang, Po-Shiuan Hsieh, Ming-Shi Shiao, Jan-Kan Chen, Dai-Er Li, Li-Man Hung

Article Affiliation:

Jiung-Pang Huang

Abstract:

BACKGROUND: We compared the insulin resistance and metabolic alterations by using a global lipidomic approach.

METHODS: Rats were fed with high-fat-diet (HFD) and high-fructose-diet (HFr) for 12 weeks to induced insulin resistance syndrome.

RESULTS: Rats on both diets developed of insulin resistance syndrome, characterized by hypertension, hyperlipidemia, hyperinsulinemia, impaired fasting glucose, and insulin resistance. Compared with HFr rats, nonesterified-fatty-acid was lower, and body weight and plasma insulin level were markedly higher in the HFD animals. Adiposity and plasma leptin levels were increased in both groups. However, the size of adipocytes in the HFD-fed rats was greater than that in the HFr-fed rats. Notably, the lipidomic heat map revealed metabolites exhibiting greater differences in the HFD and HFr-fed rats, compared with the controls. Plasma adrenic acid levels were higher in the HFD-fed rats than in the HFr-fed rats. Nevertheless, linoleic and arachidonic acid levels decreased in the HFr-fed rats. Plasma docosapentaenoic acid and docosahexaenoic acid were greatly reduced after feeding with both diets, particularly the HFr diet. Analyzing the correlation between these two fatty acids and metabolic parameters revealed a strong positive correlation between the acids and the insulin sensitivity index.

CONCLUSIONS: The systemic lipidomic analysis indicated that a reduction in these two long-chain fatty acids strongly correlated with insulin resistance in rats under long-term overnutrition. These results provide a potential therapeutic target of insulin resistance and metabolic syndrome.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2017 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.