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Abstract Title:

Dry and ripe fruit of Aegle marmelos. L: A potent source of antioxidant, lipoxygenase inhibitors and free radical scavenger.

Abstract Source:

Pak J Pharm Sci. 2016 Jul ;29(4):1127-31. PMID: 27393425

Abstract Author(s):

Atiqur Rahman, Hina Imran, Lubna Iqbal, Syed Intasar Hussain STaqvi, Nudrat Fatima, Zahra Yaqeen

Article Affiliation:

Atiqur Rahman

Abstract:

The antioxidant, lipoxygenase inhibitory activities and free radical scavenging capacity of the crude extract, aqueous and some organic fractions of dry and ripe fruit of Aeglemarmelos. L were studied to understand the protective and therapeutic role for the use of the fruit as a remedy in different ailments. All the tested fractions and extracts showed to possess significant antioxidant, free radical scavenging capacity and lipoxygenase inhibitory potential. However, chloroform and aqueous fractions showed significant ability to quench radicals, to reduce ferric chloride and to inhibit soyabean lipoxygenase. Their antioxidant and lipoxygenase inhibition was estimated by IC50 values, for antioxidant ranging from 88-65% activity at concentration of 5-0.15μ/mL and similarly for lipoxygenase inhibition ranging from 89-69% at various concentrations of 5-0.15μ/mL, in chloroform and aqueous fractions respectively. The scavenger molecules in the dry and ripe fruit of A. marmelos may attribute to therapeutic and protective effect during different progressive stages of ailments.

Study Type : In Vitro Study

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Sayer Ji
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