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Abstract Title:

Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis.

Abstract Source:

Proc Natl Acad Sci U S A. 2017 Apr 24. Epub 2017 Apr 24. PMID: 28439012

Abstract Author(s):

James A Rogers, Manoj K Mishra, Jennifer Hahn, Catherine J Greene, Robin M Yates, Luanne M Metz, V Wee Yong

Article Affiliation:

James A Rogers

Abstract:

Environmental and hormonal factors are implicated in dysimmunity in multiple sclerosis. We investigated whether bisphenol-A, a prominent contaminant with endocrine-disrupting capabilities, altered susceptibility in an inflammatory model of multiple sclerosis. We found that gestational, but not adult, exposure to bisphenol-A increased the development of experimental autoimmune encephalomyelitis in adulthood in male, but not female, mice when a suboptimal disease-inducing immunization was used. Gestational bisphenol-A in male mice primed macrophages in adulthood and raised granulocyte-colony stimulating factor and neutrophil counts/activity postsuboptimal immunization. Neutralizing granulocyte-colony stimulating factor blocked susceptibility to disease in bisphenol-A mice. Early life exposure to bisphenol-A may represent an environmental consideration in multiple sclerosis.

Study Type : Animal Study

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Sayer Ji
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