Effect of rice-expressed amyloidβ in the Tg2576 Alzheimer's disease transgenic mouse model. - GreenMedInfo Summary
Effect of rice-expressed amyloidβ in the Tg2576 Alzheimer's disease transgenic mouse model.
Vaccine. 2011 Aug 26 ;29(37):6252-8. Epub 2011 Jul 2. PMID: 21726591
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.
One of the main hallmarks of Alzheimer's disease (AD) is senile plaques composed of amyloidβ (Aβ). We developed a new edible vaccine: rice expressing GFP-Aβ42. In a previous report, we described the production of anti-Aβ antibodies in B6 mice fed Aβ rice mixed with cholera toxin B subunit (CTB). In this report, we investigated whether Aβ rice had therapeutic effects in the Tg2576 ADmodel mice. The anti-Aβ antibody titer was increased and levels of intracerebral Aβ (soluble and insoluble) and serum Aβ decreased. Because the value of IgG1/IgG2a in the Aβ feeding group was>1, immunization via Aβ rice may induce a non-inflammatory Th2 reaction. We also found that the Aβ vaccine improved memory, as assessed in a Y-maze test. The number of arm entries in the Y-maze test was lower in the Aβ feeding group than in the control group. These results suggest that the new edible vaccine Aβ ricemay have therapeutic effects in AD.