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Abstract Title:

(-)-Epigallocatechin-3-gallate (EGCG) attenuatesarsenic-induced cardiotoxicity in rats.

Abstract Source:

Food Chem Toxicol. 2016 May 8. Epub 2016 May 8. PMID: 27170490

Abstract Author(s):

Tao-Li Sun, Zhi Liu, Zheng-Jun Qi, Yong-Pan Huang, Xiao-Qin Gao, Yan-Yan Zhang

Article Affiliation:

Tao-Li Sun

Abstract:

Chronic arsenic exposure in drinking water is associated with the abnormalities of cardiac tissue. Excessive generation of ROS induced by arsenic has a central role in arsenic-induced cardiotoxicity. (-)-Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, possesses a potent antioxidant capacity and exhibits extensive pharmacological activities. This study was aim to evaluate the effect of EGCG on arsenic-induced cardiotoxicity in vivo and in vitro. Treatment with NaAsO2 seriously affected the morphology and ultrastructure of myocardium, and induced cardiac injuries, oxidative stress, intracellular calcium accumulation and apoptosis in rats. In consistent with in vivo study, the injuries, oxidative stress and apoptosis were also observed in NaAsO2-treated H9c2 cells. All of these effects induced by NaAsO2 were attenuated by EGCG. These results suggest EGCG could attenuate NaAsO2-induced cardiotoxicity, and the mechanism may involve its potent antioxidant capacity.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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